IGF-1 LR3 1mg — Long R3 Insulin-Like Growth Factor-1

IGF-1 LR3 is an 83-amino-acid analog of human insulin-like growth factor-1, engineered for the research setting. It carries the native 70-residue IGF-1 sequence with arginine substituted for glutamic acid at position 3, plus a 13-residue N-terminal extension — modifications that sharply reduce its affinity for the IGF-binding proteins that normally sequester circulating IGF-1 within minutes. The result is an analog that stays free and receptor-available for roughly a day rather than minutes, making it one of the most widely used tools for studying sustained IGF-axis signaling.

Why the “Long R3” modification matters

In circulation, native IGF-1 is almost entirely bound by IGFBP-1 through IGFBP-6, leaving only a small free fraction available to the receptor. The Arg3 substitution weakens IGFBP binding while the N-terminal extension stabilizes the molecule, so Long R3 IGF-1 remains free far longer than native IGF-1. This property was first exploited in mammalian cell-culture research, where Long R3 IGF-1 became a standard supplement for sustaining the viability and productivity of cultured cells in reduced-serum media.

Specifications

Analog	83-residue IGF-1 analog (Arg3 substitution + 13-residue N-terminal extension)
Molecular Weight	~9111 g/mol
CAS Number	946870-92-4
Molecular Purity	See COA
Form	Lyophilized powder
Reconstitution	Bacteriostatic (BAC) water
Storage	Cool, dry, away from direct light
Quantity	1mg per vial

Research areas

IGF-1 receptor signaling

Studied for activation of the IGF-1 receptor and the downstream PI3K/Akt and MAPK cascades that govern cellular growth, proliferation, and survival.

Cell-culture research

A standard supplement in serum-free and reduced-serum mammalian cell culture, studied for its ability to sustain cell viability and product yield.

Protein-synthesis models

Investigated in skeletal-muscle and connective-tissue models for its role in protein-synthesis signaling and cellular hypertrophy and hyperplasia pathways.

Metabolic research

Examined for cross-talk with insulin signaling and glucose-uptake pathways in metabolic research models.

Research applications

Studied in IGF-1 receptor and PI3K/Akt signaling research
Used as a supplement in mammalian cell-culture models
Relevant to protein-synthesis and tissue-growth pathway research
Investigated in metabolic and nutrient-partitioning models
Used to study sustained IGF-axis activation versus native IGF-1

For research use only. Not for human consumption.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

Reviews

There are no reviews yet.

Be the first to review “IGF-1 LR3”

IGF-1 LR3