MOTS-C
Price range: $35.00 through $119.00
Mitochondrial-derived peptide — 16 amino acids encoded by the 12S rRNA gene region First described in 2015 — studied in AMPK pathway activation and mitochondrial-nuclear signaling Research-grade · CAS 1627580-64-6 For in vitro metabolic pathway research only
MOTS-C 10mg — Mitochondrial-Derived Peptide
Specifications
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Amino Acids | 16 |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.64 g/mol |
| CAS Number | 1627580-64-6 |
| Gene Origin | Mitochondrial 12S rRNA gene region |
| Form | Lyophilized powder |
| Quantity | 10mg per vial |
An indirect route to AMPK
MOTS-C does not hit AMPK directly the way pharmaceutical activators do. Instead, it inhibits the folate cycle, which causes AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) to accumulate. AICAR is an endogenous AMPK activator. So MOTS-C activates the central energy sensor of the cell, but through an upstream metabolic bottleneck rather than direct kinase binding. Under stress conditions, the peptide translocates from mitochondria to the nucleus to regulate gene expression — a retrograde signal where the organelle talks back to the genome.
MOTS-C vs NAD+
Both sit at the intersection of energy metabolism and cellular signaling, but through different nodes. NAD+ fuels sirtuins, PARPs, and the electron transport
| MG Option | 10mg, 40mg |
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